All the blood in the body is continually filtered through the kidneys. These two large, bean-shaped organs get rid of many of the body’s waste products and poisons by producing urine. Blood cells and large molecules such as proteins are held back by the kidneys. There is a continual trading of chemicals back and forth. If there is too much of something in the blood—a salt, for example—the excess passes into the urine. If there is only just enough of a substance, or a shortage of it, the kidneys will return it to the blood.
In a healthy person, there is just the right amount of glucose in the blood, so the kidneys hold it all back. Normally there is no sugar in the urine. But when the blood sugar level rises beyond about 180 mg%, the renal threshold, the excess sugar begins to “spill” over into the urine, like extra water over a dam. The presence of glucose in the urine is called glucosuria.
There must always be enough water in the urine to keep irritating and poisonous wastes well diluted. As the amount of glucose spilling into the urine increases, the urine becomes more concentrated. So the kidneys must pass out more water to keep the urine diluted enough. Then the body becomes dehydrated, and the person becomes thirsty. With all the extra water flowing out through the kidneys, minerals are washed out too, along with proteins and fats, which are not normally excreted by the kidneys. So a person with uncontrolled diabetes begins to lose weight.
Meanwhile, despite all that sugar floating around in the blood, the person is unable to use sugar effectively as a fuel for normal body activities. Chemical distress signals are sent out by the hungry cells, and a metabolic switch-over begins. The body begins to raid its fat stores for energy fuel, and it may even begin to pull protein from the muscles. (That’s like a family who have run out of fuel oil chopping up their furniture and burning it in the fireplace to keep warm—it may solve the problem temporarily, but it creates even worse problems later on.)
When fats are broken down for energy, chemicals called ketone bodies are formed as by-products. These build up in the blood and spill over into the urine; they may give the breath a distinctive “fruity,” acetone odor. Ketone bodies are somewhat acid, and they upset the acid balance of the blood. This is a delicate balance, and it is normally maintained within very narrow limits. Too much acid can poison or even kill body cells. If too much fat must be used to provide energy because there is not enough insulin to allow the use of glucose for fuel, a state called ketoacidosis develops. The person may lose consciousness, may go into a coma, and—if not rescued by prompt medical treatment may die.
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Category: Diabetes
TYPE I DIABETES AND EFFECTS ON THE KIDNEYS
THE CARBOHYDRATE ADDICT’S PROFILE
THE G.I. FACTOR: ANSWERED QUESTIONS
Does the G.I. factor predict the glycaemic effect of a normal serving of food?
Although the G.L is based on 50 gram carbohydrate portions, the ranking of foods is roughly the same when compared on a per usual serving size, per 1000 kilojoule or per 100 gram food basis. There are some exceptions to this, one being carrots. You can eat as many carrots as you wish despite their high G.I.
Studies have shown that even though the G.L factor has been determined on the basis of a 50 gram carbohydrate portion, it can be used to predict the effect of a normal serve size with a meal. This is why the long-term studies of real people with diabetes eating real low G.L meals have been successful.
Would a person with diabetes need to reduce their insulin dose if they changed to low G.I. foods?
It is possible that if a person with well controlled diabetes changes their carbohydrate to low G.I. types that they could reduce their insulin dosage and maintain the same blood sugar levels. While we have heard anecdotes of this occurring, it has not been demonstrated in any scientific studies.
Does the G.I. factor of a food only apply to a certain quantity of the food?
No. The G.I. factor of a food remains the same whether you eat 10 grams of the food or 1000 grams of the food. Because it is a ranking of one carbohydrate food to another according to glycaemic impact, to make the comparison fair, the amount of each food being compared must be the same. This is why a 50 gram (usually) carbohydrate portion of a food is compared to 50 grams of glucose or a 50 gram carbohydrate portion of white bread, when the G.I. factor is being measured. What does change with the quantity of food, is the actual glycaemic effect of that food in the body. We can eat less of a high G.I. food or more of a low G.I. food and end up with the same blood sugar responses.
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LIVING WITH DIABETES: DIABETES AUSTRALIA
Diabetes Associations are well established in most countries. Most of their members are people with diabetes whose aim is to help themselves and other people with diabetes lead a full and healthy life. Thus they may help in many ways, such as advice with social, diet, employment and travel problems, or information about the medical and other facilities available for people with diabetes. Many diabetic associations run holiday camps for children with diabetes, and publish a regular magazines and booklets giving information of interest to people with diabetes.
Diabetes Australia, like most Diabetes Associations, has a medical and scientific section for doctors and scientists who specialize in the care of diabetes, or who are involved with research in diabetes. There is also an association of Diabetes Educators. This leads to cooperation and the sharing of knowledge at all levels of care of those with diabetes. A very important aspect of this association is the support and sponsoring of research in diabetes.
You will probably want to join your state branch of Diabetes Australia because it could be very helpful to you, and it will allow you to support an organization which is established to help all persons with diabetes in the community by advice, information, negotiation with outside bodies and in research.
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